10 20 30 40 50 60 | | | | | |beefcore2 ----------------SLKVAPKVKATEAPAGVPPHP--QDLEFTRLPNGLVIASLEN-Ychickcore2 MRRFSLPARSLAKRLYSLKVAPKVAVSAAAERVKLCPGAEDLEITKLPNGLIIASLEN-Fbeefcore1 ----------------------------TATYAQALQSVPETQVSQLDNGLRVASEQS-Schickcore1 -------------GRVLRGLLPLTRNRGAATYAQTLQNIPETNVTTLDNGLRVASEES-SMPP_beta_Sc ----------------MFSRTASKFRNTRRLLSTISSQIPGTRTSKLPNGLTIATEYIPNyeastcore1 ---------------MLRTVTSKTVSNQFKRSLATAVATPKAEVTQLSNGIVVATEHNPSMPP_alph_Sc -----------------------MLRNGVQRLYSNIARTDNFKLSSLANGLKVATSNT-Pyeastcore2 -----------------------------------MLSAARLQFAQGSVRRLTVSARDAP . : .: Prim.cons. MRRFSLPARSLAK33----2-223-2N2AA222QTL2S3P22EVTQLPNGL2VASEEN-S 70 80 90 100 110 120 | | | | | |beefcore2 APASRIGLFIKAGSRYENSNNLGTSHLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTchickcore2 SPASRIGVFIKAGSRYETTANLGTAHLLRLASPLTTKGASSFRITRGIEAVGGSLSVYSTbeefcore1 QPTCTVGVWIDAGSRYESEKNNGAGYFVEHLAFKGTKNRPGNALEKEVESMGAHLNAYSTchickcore1 QPTCTVGVWIGAGSRYENEKNNGAGYFVEHLAFKGTKKRPCAAFEKEVESMGAHFNGYTSMPP_beta_Sc TSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRPQQGIELEIENIGSHLNAYTSyeastcore1 AHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENS-------AVAAKEGLALSSNISMPP_alph_Sc GHFSALGLYIDAGSRFEGRNLKGCTHILDRLAFKSTEHVEGRAMAETLELLGGNYQCTSSyeastcore2 TKISTLAVKVHGGSRYATKD--GVAHLLNRFNFQNTNTRSALKLVRESELLGGTFKSTLD . :.: . .*: * : : * . Prim.cons. 3PTSTVGVFIDAGSRYENEKNNGTAHLLEHLAFKGTK2R22FAIEREIE33GGHL23YSS 130 140 150 160 170 180 | | | | | |beefcore2 RENMAYTVECLRDDVDILMEFLLN---VTTAPEFRRWEVAALQPQLRIDKAVAL-QNPQAchickcore2 REKMTYCVECLRDHVDTVMEYLLN---VTTAPEFRPWEVTDLQPQLKVDKAVAF-QSPQVbeefcore1 REHTAYYIKALSKDLPKAVELLAD---IVQNCSLEDSQIEKERDVILQELQEND-TSMRDchickcore1 REQTAFYIKALSKDMPKVVELLAD---VVQNCALEESQIEKERGVILQELKEMD-NDMTNMPP_beta_Sc RENTVYYAKSLQEDIPKAVDILSD---ILTKSVLDNSAIERERDVIIRESEEVD-KMYDEyeastcore1 RDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLKQVQDFEENDHPNMPP_alph_Sc RENLMYQASVFNQDVGKMLQLMSET---VRFPKITEQELQEQKLSAEYEIDEVW-MKPELyeastcore2 REYITLKATFLKDDLPYYVNALAD---VLYKTAFKPHELTESVLPAARYDYAVAEQCPVK *: : :: : : : . Prim.cons. RENTAYY2K3L2DDVPK2VELLAD---VVTAP2L22SEIE3ER3VIL2E22EVD-Q2PQN 190 200 210 220 230 240 | | | | | |beefcore2 HVIENLHAAAYRN-ALANSLYCPDYRIGKVTPVELHDYVQNHFTSARMALIGLG-VSHPVchickcore2 GVLENLHAAAYKT-ALANPLYCPDYRIGKITSEQLHHFVQNNFTSARMALVGIG-VKHSDbeefcore1 VVFNYLHATAFQGTPLAQSVEGPSENVRKLSRADLTEYLSRHYKAPRMVLAAAGGLEHRQchickcore1 VTFDYLHATAFQGTALARTVEGTTENIKHLTRADLASYIDTHFKAPRMVLAAAGGISHKEMPP_beta_Sc VVFDHLHEITYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHEKyeastcore1 RVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNAVVVGTGNIKHEDMPP_alph_Sc VLPELLHTAAYSGETLGSPLICPRELIPSISKYYLLDYRNKFYTPENTVAAFVG-VPHEKyeastcore2 SAEDQLYAITFRK-GLGNPLLYDG--VERVSLQDIKDFADKVYTKENLEVSGENVVEADL : *: :: *. . : : : : : . . : Prim.cons. VVFE3LHA2A2QGT2LANPL3GPDENI3K2TRADL2DY332H2T23RMVLAGAG2V3HE2 250 260 270 280 290 300 | | | | | |beefcore2 LKQVAEQFLNIRG---------GLGLSGAKAKYHGGEIREQN------GDSLVHAALVAEchickcore2 LKQVAEQFLNIRS---------GAGTSSAKATYWGGEIREQN------GHSLVHAAVVTEbeefcore1 LLDLAQKHFSGLS----GTYDEDAVPTLSPCRFTGSQICHRED-----GLPLAHVAIAVEchickcore1 LVDAARQHFSGVS-F---TYKEDAVPILPRCRFTGSEIRARDD-----ALPVAHVALAVEMPP_beta_Sc LVQYAQKYFGHVP--KSESPVPLGSPRGPLPVFCRGERFIKEN-----TLPTTHIAIALEyeastcore1 LVNSIESKNLSLQ-------TGTKPVLKKKAAFLGSEVRLRDD-----TLPKAWISLAVEMPP_alph_Sc ALELTEKYLGDWQ-------STHPPITKKVPQYTGGESCIPPAPVFGNLPELFHIQIGFEyeastcore2 KRFVDESLLSTLP------AGKSLVSKSEPKFFLGEENRVRF-------IGDSVAAIGIP .. : : : Prim.cons. LVQVAE23LS2LS-------7E2AVP243KARFTGGEIR2R3D-----GLPLAH2AIAVE 310 320 330 340 350 360 | | | | | |beefcore2 SAAIGSAEANAFSVLQHVLGAGPHVK---RGSNATSSLYQAVAKGVHQPFDVSAFNASYSchickcore2 GAAVGSAEANAFSVLQHVLGAGPLIK---RGSSVTSKLYQGVAKATTQPFDASAFNVNYSbeefcore1 GPGWAHPDNVALQVANAIIGHYDCTYG--GGAHLSSPLASIAATNKL-CQSFQTFNICYAchickcore1 GPGWADPDNVVLHVANAIIGRYDRTFG--GGKHLSSRLAALAVEHKL-CHSFQTFNTSYSMPP_beta_Sc GVSWSAPDYFVALATQAIVGNWDRAIG--TGTNSPSPLAVAASQNGSLANSYMSFSTSYAyeastcore1 GEPVNSPNYFVAKLAAQIFGSYNAFE---PASRLQGIKLLDNIQEYQLCDNFNHFSLSYKMPP_alph_Sc GLPIDHPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTHVLNQYYFVENCVAFNHSYSyeastcore2 VNK---ASLAQYEVLANYLT-----------SALSELSGLI----------SSAKLDKFT .. . : Prim.cons. G23W2SPD33ALSVLQAILGA2DR2K2--3GS2LSS2L2222A2N2L3CFSFSAFNTSYS 370 380 390 400 410 420 | | | | | |beefcore2 DSGLFGFYTISQ---AASAGDVIK-AAYNQVKTIAQGNLSNPDVQAAKNKLKAGYLMSVEchickcore2 DSGLFGFYTISQ---AAHAGEVIR-AAMNQLKAAAQGGVTEEDVTKAKNQLKATYLMSVEbeefcore1 DTGLLGAHFVCDH---MSIDDMMF-VLQGQWMRLCT-SATESEVLRGKNLLRNALVSHLDchickcore1 DTGLFGFHFVADP---LSIDDMM--CAQGEWMRLCT-STTESEVKRAKNHLRSAMVAQLDMPP_beta_Sc DSGLWGMYIVTDS--NEHNVRLIVNEILKEWKRIKSGKISDAEVNRAKAQLKAALLLSLDyeastcore1 DSGLWGFSTATRN--VTMIDDLIH-FTLKQWNRLTI-SVTDTEVERAKSLLKLQLGQLYEMPP_alph_Sc DSGIFGISLSCIPQAAPQAVEVIAQQMYNTFANKDL-RLTEDEVSRAKNQLKSSLLMNLEyeastcore2 DGGLFTLFVRDQ---DSAVVSSNIKKIVADLKKG-------KDLSPAINYTKLKNAVQN- * *: :: . : Prim.cons. DSGLFGFYTV322--AAS22DVI8-AA3NQWKRL22-S2TESEVSRAKNQLKAALLMSLE 430 440 450 460 470 480 | | | | | |beefcore2 SSEGFLDE--VGSQALAAGSYTPPSTVLQQIDAVADADVINAAKK---FVSGRKSMAASGchickcore2 TAQGLLNE--IGSEALLSGTHTAPSVVAQKIDSVTSADVVNAAKK---FVSGKKSMAASGbeefcore1 GTTPVCED--IGRSLLTYGRRIPLAEWESRIAEVDARVVREVCSKY--FYDQCPAVAGFGchickcore1 GTTPVCET--IGSHLLNYGRRISLEEWDSRISAVDARMVRDVCSKY--IYDKCPALAAVGMPP_beta_Sc GSTAIVED--IGRQVVTTGKRLSPEEVFEQVDKITKDDIIMWANYR--LQNKPVSMVALGyeastcore1 SGNPVNDANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKR--LWDQDIAIAGTGMPP_alph_Sc SKLVELED--MGRQVLMHGRKIPVNEMISKIEDLKPDDISRVAEM---IFTGNVNNAGNGyeastcore2 -----------------ESVSSPIELNFDAVKDFKL---------------GKFNYVAVG . . . : . .. *Prim.cons. 22TPVLED--IG2QVLTYGRRIP2EEVFSKIDAVTA3DV2NVA2K3--F2DG232MAA2G 490 500 510 520 | | | |beefcore2 NLGHTPFIDEL---------------------------------chickcore2 DLGSTPFLDEL---------------------------------beefcore1 PIEQLPDYNRIRSGMFWLRF------------------------chickcore1 PIEQLLDYNRIRSGMYWIRF------------------------MPP_beta_Sc NTSTVPNVSYIEEKLNQ---------------------------yeastcore1 QIEGLLDYMRIRSDMSMMRW------------------------MPP_alph_Sc KGRATVVMQGDRGSFGDVENVLKAYGLGNSSSSKNDSPKKKGWFyeastcore2 DVSNLPYLDEL---------------------------------Prim.cons. 3IEQLPDYD2IRS2M-2-2------------------------F 1 beefcore1 2 MPP_beta_Sc 3 yeastcore1 4 MPP_alph_Sc 5 beefcore2 6 yeastcore2 bfc1 MPPB ysc1 MPPA bfc2 ysc2 1 -- -- M1 -- -- -- 2 -- M1 L2 -- -- -- 3 -- F2 R3 -- -- -- 4 -- S3 T4 -- S1* -- 5 -- R4 V5 -- L2 -- 6 -- T5 T6 -- K3 -- 7 -- A6 S7 -- V4 -- 8 -- S7 K8 -- A5 -- 9 -- K8 T9 M1 P6 -- 10 -- F9 V10 L2 K7 -- 11 -- R10 S11 R3 V8 -- 12 -- N11 N12 N4 K9 -- 13 -- T12 Q13 G5 A10 -- 14 T1* R13 F14 V6 T11 -- 15 A2 R14 K15 Q7 E12 -- 16 T3 L15 R16 R8 A13 -- 17 Y4 L16 S17 L9 P14 -- 18 A5 S17 L18* Y10 A15 -- N-term yeast COR1 19 Q6 T18 A19 S11 G16 -- 20 A7 I19 T20 N12 V17 -- 21 L8 S20 A21 I13 P18 M1 22 Q9 S21 V22 A14 P19 L2 23 S10 Q22 A23 R15 H20 S3 24 V11 I23 T24 T16 P21 A4 25 P12 P24 P25 D17 Q22 A5 26 E13 G25 K26 N18 D23 R6 27 T14 T26 A27 F19 L24 L7 28 Q15 R27 E28 K20 E25 Q8 29 V16 T28 V29 L21 F26 F9 30 S17 S29 T30 S22 T27 A10 31 Q18 K30 Q31 S23 R28 Q11 32 L19 L31 L32 L24 L29 G12 33 D20 P32 S33 A25 P30 S13 34 N21 N33 N34 N26 N31 V14 35 G22 G34 G35 G27 G32 R15 36 L23 L35 I36 L28 L33 R16 37 R24 T36 V37 K29 V34 L17* N-term yeast QCR2 38 V25 I37 V38 V30 I35 T18 39 A26 A38 A39 A31 A36 V19 40 S27 T39 T40 T32 S37 S20 41 E28 E40 E41 S33 L38 A21 42 Q29 Y41 H42 N34 E39 R22 43 S30 I42 N43 T35 N40 D23 44 -- P43 P44 -- -- A24 45 S31 N44 S45 P36 Y41 P25 46 Q32 T45 A46 G37 A42 T26 47 P33 S46 H47 H38 P43 K27 48 T34 S47 T48 F39 A44 I28 49 C35 A48 A49 S40 S45 S29 bfc1 MPPB ysc1 MPPA bfc2 ysc2 50 T36 T49 S50 A41 R46 T30 51 V37 V50 V51 L42 I47 L31 52 G38 G51 G52 G43 G48 A32 53 V39 I52 V53 L44 L49 V33 54 W40 F53 V54 Y45 F50 K34 55 I41 V54 F55 I46 I51 V35 56 D42 D55 G56 D47 K52 H36 57 A43 A56 S57 A48 A53 G37 58 G44 G57 G58 G49 G54 G38 59 S45 S58 A59 S50 S55 S39 60 R46 R59 A60 R51 R56 R40 61 Y47 A60 N61 F52 Y57 Y41 62 E48 E61 E62 E53 E58 A42 63 S49 N62 N63 G54 N59 T43 64 E50 V63 P64 R55 S60 K44 65 K51 K64 Y65 N56 N61 D45 66 N52 N65 N66 L57 N62 -- 67 N53 N66 N67 K58 L63 -- 68 G54 G67 G68 G59 G64 G46 69 A55 T68 V69 C60 T65 V47 70 G56 A69 S70 T61 S66 A48 71 Y57 H70 N71 H62 H67 H49 72 F58 F71 L72 I63 L68 L50 73 V59 L72 W73 L64 L69 L51 74 E60 E73 K74 D65 R70 N52 75 H61 H74 N75 R66 L71 R53 76 L62 L75 I76 L67 A72 F54 77 A63 A76 F77 A68 S73 N55 78 F64 F77 L78 F69 S74 F56 79 K65 K78 S79 K70 L75 Q57 80 G66 G79 K80 S71 T76 N58 81 T67 T80 E81 T72 T77 T59 82 K68 Q81 N82 E73 K78 N60 83 N69 N82 S83 H74 G79 T61 84 R70 R83 -- V75 A80 R62 85 P71 P84 -- E76 S81 S63 86 G72 Q85 -- G77 S82 A64 87 N73 Q86 -- R78 F83 L65 88 A74 G87 -- A79 K84 K66 89 L75 I88 -- M80 I85 L67 90 E76 E89 -- A81 T86 V68 91 K77 L90 A84 E82 R87 R69 92 E78 E91 V85 T83 G88 E70 93 V79 I92 A86 L84 I89 S71 94 E80 E93 A87 E85 E90 E72 95 S81 N94 K88 L86 A91 L73 96 M82 I95 E89 L87 V92 L74 97 G83 G96 G90 G88 G93 G75 98 A84 S97 L91 G89 G94 G76 99 H85 H98 A92 N90 K95 T77 bfc1 MPPB ysc1 MPPA bfc2 ysc2 100 L86 L99 L93 Y91 L96 F78 101 N87 N100 S94 Q92 S97 K79 102 A88 A101 S95 C93 V98 S80 103 Y89 Y102 N96 T94 T99 T81 104 S90 T103 I97 S95 S100 L82 105 T91 S104 S98 S96 T101 D83 106 R92 R105 R99 R97 R102 R84 107 E93 E106 D100 E98 E103 E85 108 H94 N107 F101 N99 N104 Y86 109 T95 T108 Q102 L100 M105 I87 110 A96 V109 S103 M101 A106 T88 111 Y97 Y110 Y104 Y102 Y107 L89 112 Y98 Y111 I105 Q103 T108 K90 113 I99 A112 V106 A104 V109 A91 114 K100 K113 S107 S105 E110 T92 115 A101 S114 S108 V106 C111 F93 116 L102 L115 L109 F107 L112 L94 117 S103 Q116 P110 N108 R113 K95 118 K104 E117 G111 Q109 D114 D96 119 D105 D118 S112 D110 D115 D97 120 L106 I119 T113 V111 V116 L98 121 P107 P120 D114 G112 D117 P99 122 K108 K121 K115 K113 I118 Y100 123 A109 A122 S116 M114 L119 Y101 124 V110 V123 L117 L115 M120 V102 125 E111 D124 D118 Q116 E121 N103 126 L112 I125 F119 L117 F122 A104 127 L113 L126 L120 M118 L123 L105 128 A114 S127 N121 S119 L124 A106 129 D115 D128 Q122 E120 N125 D107 130 -- -- S123 T121 -- -- 131 -- -- F124 -- -- -- 132 -- -- I125 -- -- -- 133 I116 I129 Q126 -- V126 V108 134 V117 L130 Q127 V122 T127 L109 135 Q118 T131 K128 R123 T128 Y110 136 N119 K132 A129 F124 A129 K111 137 C120 S133 N130 P125 P130 T112 138 S121 V134 L131 K126 E131 A113 139 L122 L135 L132 I127 F132 F114 140 E123 D136 S133 T128 R133 K115 141 D124 N137 S134 E129 R134 P116 142 S125 S138 S135 Q130 W135 H117 143 Q126 A139 N136 E131 E136 E118 144 I127 I140 F137 L132 V137 L119 145 E128 E141 E138 Q133 A138 T120 146 K129 R142 A139 E134 A139 E121 147 E130 E143 T140 Q135 L140 S122 148 R131 R144 K141 K136 Q141 V123 149 D132 D145 K142 L137 P142 L124 bfc1 MPPB ysc1 MPPA bfc2 ysc2 150 V133 V146 S143 S138 Q143 P125 151 I134 I147 V144 A139 L144 A126 152 L135 I148 L145 E140 R145 A127 153 Q136 R149 K146 Y141 I146 R128 154 E137 E150 Q147 E142 D147 Y129 155 L138 S151 V148 I143 K148 D130 156 Q139 E152 Q149 D144 A149 Y131 157 E140 E153 D150 E145 V150 A132 158 N141 V154 F151 V146 A151 V133 159 D142 D155 E152 W147 L152 A134 160 -- -- E153 -- -- E135 161 T143 K156 N154 M148 Q153 Q136 162 S144 M157 D155 K149 N154 C137 163 M145 Y158 H156 P150 P155 P138 164 R146 D159 P157 E151 Q156 V139 165 D147 E160 N158 L152 A157 K140 166 V148 V161 R159 V153 H158 S141 167 V149 V162 V160 L154 V159 A142 168 F150 F163 L161 P155 I160 E143 169 N151 D164 E162 E156 E161 D144 170 Y152 H165 H163 L157 N162 Q145 171 L153 L166 L164 L158 L163 L146 172 H154 H167 H165 H159 H164 Y147 173 A155 E168 S166 T160 A165 A148 174 T156 I169 T167 A161 A166 I149 175 A157 T170 A168 A162 A167 T150 176 F158 Y171 F169 Y163 Y168 F151 177 Q159 K172 Q170 S164 R169 R152 178 G160 D173 N171 G165 N170 K153 179 T161 Q174 T172 E166 -- -- 180 P162 P175 P173 T167 A171 G154 181 L163 L176 L174 L168 L172 L155 182 A164 G177 S175 G169 A173 G156 183 Q165 R178 L176 S170 N174 N157 184 S166 T179 P177 P171 S175 P158 185 V167 I180 T178 L172 L176 L159 186 E168 L181 R179 I173 Y177 L160 187 G169 G182 G180 C174 C178 Y161 188 P170 P183 T181 P175 P179 D162 189 S171 I184 L182 R176 D180 G163 190 E172 K185 E183 E177 Y181 -- 191 N173 N186 S184 L178 R182 -- 192 V174 I187 L185 I179 I183 V164 193 R175 K188 E186 P180 G184 E165 194 K176 S189 N187 S181 K185 R166 195 L177 I190 L188 I182 V186 V167 196 S178 T191 V189 S183 T187 S168 197 R179 R192 V190 K184 P188 L169 198 A180 T193 A191 Y185 V189 Q170 199 D181 D194 D192 Y186 E190 D171 bfc1 MPPB ysc1 MPPA bfc2 ysc2 200 L182 L195 L193 L187 L191 I172 201 T183 K196 E194 L188 H192 K173 202 E184 D197 S195 D189 D193 D174 203 Y185 Y198 F196 Y190 Y194 F175 204 L186 I199 A197 R191 V195 A176 205 S187 T200 N198 N192 Q196 D177 206 R188 K201 N199 K193 N197 K178 207 H189 N202 H200 F194 H198 V179 208 Y190 Y203 F201 Y195 F199 Y180 209 K191 K204 L202 T196 T200 T181 210 A192 G205 N203 P197 S201 K182 211 P193 D206 S204 E198 A202 E183 212 R194 R207 N205 N199 R203 N184 213 M195 M208 A206 T200 M204 L185 214 V196 V209 V207 V201 A205 E186 215 L197 L210 V208 A202 L206 V187 216 A198 A211 V209 A203 I207 S188 217 A199 G212 G210 F204 G208 G189 218 A200 A213 T211 V205 L209 E190 219 G201 G214 G212 G206 G210 N191 220 G202 A215 N213 -- -- V192 221 L203 V216 I214 V207 V211 V193 222 E204 D217 K215 P208 S212 E194 223 H205 H218 H216 H209 H213 A195 224 R206 E219 E217 E210 P214 D196 225 Q207 K220 D218 K211 V215 L197 226 L208 L221 L219 A212 L216 K198 227 L209 V222 V220 L213 K217 R199 228 D210 Q223 N221 E214 Q218 F200 229 L211 Y224 S222 L215 V219 V201 230 A212 A225 I223 T216 A220 D202 231 Q213 Q226 E224 E217 E221 E203 232 K214 K227 S225 K218 Q222 S204 233 H215 Y228 K226 Y219 F223 L205 234 F216 F229 N227 L220 L224 L206 235 S217 G230 L228 G221 N225 S207 236 G218 H231 S229 D222 I226 T208 237 L219 V232 L230 W223 R227 L209 238 S220 P233 Q231 Q224 G228 P210 239 -- -- -- -- -- -- 240 -- -- -- -- -- -- 241 -- K234 -- -- -- -- 242 -- S235 -- -- -- -- 243 G221 E236 -- -- -- -- 244 T222 S237 -- -- -- -- 245 Y223 P238 -- -- -- A211 246 D224 V239 T232 S225 -- G212 247 E225 P240 G233 T226 -- K213 248 D226 L241 T234 H227 G229 S214 249 A227 G242 K235 P228 L230 L215 bfc1 MPPB ysc1 MPPA bfc2 ysc2 250 V228 S243 P236 P229 G231 V216 251 P229 P244 V237 I230 L232 S217 252 T230 R245 L238 T231 S233 K218 253 L231 G246 K239 K232 G234 S219 254 S232 P247 K240 K233 A235 E220 255 P233 L248 K241 V234 K236 P221 256 C234 P249 A242 P235 A237 K222 257 R235 V250 A243 Q236 K238 F223 258 F236 F251 F244 Y237 Y239 F224 259 T237 C252 L245 T238 H240 L225 260 G238 R253 G246 G239 G241 G226 261 S239 G254 S247 G240 G242 E227 262 Q240 E255 E248 E241 E243 E228 263 I241 R256 V249 S242 I244 N229 264 C242 F257 R250 C243 R245 R230 265 H243 I258 L251 I244 E246 V231 266 R244 K259 R252 P245 Q247 R232 267 E245 E260 D253 P246 N248 F233 268 D246 N261 D254 A247 -- -- 269 -- -- -- P248 -- -- 270 -- -- -- V249 -- -- 271 -- -- -- F250 -- -- 272 -- -- -- G251 -- -- 273 -- -- -- N252 -- -- 274 G247 T262 T255 L253 G249 -- 275 L248 L263 L256 P254 D250 I234 276 P249 P264 P257 E255 S251 G235 277 L250 T265 K258 L256 L252 D236 278 A251 T266 A259 F257 V253 S237 279 H252 H267 W260 H258 H254 V238 280 V253 I268 I261 I259 A255 A239 281 A254 A269 S262 Q260 A256 A240 282 I255 I270 L263 I261 L257 I241 283 A256 A271 A264 G262 V258 G242 284 V257 L272 V265 F263 A259 I243 285 E258 E273 E266 E264 E260 P244 286 G259 G274 G267 G265 S261 V245 287 P260 V275 E268 L266 A262 N246 288 G261 S276 P269 P267 A263 K247 289 W262 W277 V270 I268 I264 -- 290 A263 S278 N271 D269 G265 -- 291 H264 A279 S272 H270 S266 -- 292 P265 P280 P273 P271 A267 A248 293 D266 D281 N274 D272 E268 S249 294 N267 Y282 Y275 I273 A269 L250 295 V268 F283 F276 Y274 N270 A251 296 A269 V284 V277 A275 A271 Q252 297 L270 A285 A278 L276 F272 Y253 298 Q271 L286 K279 A277 S273 E254 299 V272 A287 L280 T278 V274 V255 bfc1 MPPB ysc1 MPPA bfc2 ysc2 300 A273 T288 A281 L279 L275 L256 301 N274 Q289 A282 Q280 Q276 A257 302 A275 A290 Q283 T281 H277 N258 303 I276 I291 I284 L282 V278 Y259 304 I277 V292 F285 L283 L279 L260 305 G278 G293 G286 G284 G280 T261 306 H279 N294 S287 G285 A281 -- 307 Y280 W295 Y288 G286 G282 -- 308 D281 D296 N289 G287 P283 -- 309 C282 R297 A290 S288 H284 -- 310 T283 A298 F291 F289 V285 -- 311 Y284 I299 E292 S290 K286 -- 312 G285 G300 -- A291 -- -- 313 -- -- -- G292 -- -- 314 -- -- -- G293 -- -- 315 G286 T301 P293 P294 R287 -- 316 G287 G302 A294 G295 G288 -- 317 A288 T303 S295 K296 S289 S262 318 H289 N304 R296 G297 N290 A263 319 L290 S305 L297 M298 A291 L264 320 S291 P306 Q298 Y299 T292 S265 321 S292 S307 G299 S300 S293 E266 322 P293 P308 I300 R301 S294 L267 323 L294 L309 K301 L302 L295 S268 324 A295 A310 L302 Y303 Y296 G269 325 S296 V311 L303 T304 Q297 L270 326 I297 A312 D304 H305 A298 I271 327 A298 A313 N305 V306 V299 -- 328 A299 S314 I306 L307 A300 -- 329 T300 Q315 Q307 N308 K301 -- 330 N301 N316 E308 Q309 G302 -- 331 K302 G317 Y309 Y310 V303 -- 332 L303 S318 Q310 Y311 H304 -- 333 -- L319 L311 F312 Q305 -- 334 C304 A320 C312 V313 P306 -- 335 Q305 N321 D313 E314 F307 -- 336 S306 S322 N314 N315 D308 -- 337 F307 Y323 F315 C316 V309 S272 338 Q308 M324 N316 V317 S310 S273 339 T309 S325 H317 A318 A311 A274 340 F310 F326 F318 F319 F312 K275 341 N311 S327 S319 N320 N313 L276 342 I312 T328 L320 H321 A314 D277 343 C313 S329 S321 S322 S315 K278 344 Y314 Y330 Y322 Y323 Y316 F279 345 A315 A331 K323 S324 S317 T280 346 D316 D332 D324 D325 D318 D281 347 T317 S333 S325 S326 S319 G282 348 G318 G334 G326 G327 G320 G283 349 L319 L335 L327 I328 L321 L284 bfc1 MPPB ysc1 MPPA bfc2 ysc2 350 L320 W336 W328 F329 F322 F285 351 G321 G337 G329 G330 G323 T286 352 A322 M338 F330 I331 F324 L287 353 H323 Y339 S331 S332 Y325 F288 354 F324 I340 T332 L333 T326 V289 355 V325 V341 A333 S334 I327 R290 356 C326 T342 T334 C335 S328 D291 357 D327 D343 R335 I336 Q329 Q292 358 H328 S344 N336 P337 -- -- 359 -- -- -- Q338 -- -- 360 -- -- -- A339 -- -- 361 -- N345 V337 A340 A330 D293 362 M329 E346 T338 P341 A331 S294 363 S330 H347 M339 Q342 S332 A295 364 I331 N348 I340 A343 A333 V296 365 D332 V349 D341 V344 G334 V297 366 D333 R350 D342 E345 D335 S298 367 M334 L351 L343 V346 V336 S299 368 M335 I352 I344 I347 I337 N300 369 F336 V353 H345 A348 K338 I301 370 -- N354 -- Q349 -- K302 371 V337 E355 F346 Q350 A339 K303 372 L338 I356 T347 M351 A340 I304 373 Q339 L357 L348 Y352 Y341 V305 374 G340 K358 K349 N353 N342 A306 375 Q341 E359 Q350 T354 Q343 D307 376 W342 W360 W351 F355 V344 L308 377 M343 K361 N352 A356 K345 K309 378 R344 R362 R353 N357 T346 K310 379 L345 I363 L354 K358 I347 G311 380 C346 K364 T355 D359 A348 -- 381 T347 S365 I356 L360 Q349 -- 382 -- G366 -- -- G350 -- 383 S348 K367 S357 R361 N351 -- 384 A349 I368 V358 L362 L352 -- 385 T350 S369 T359 T363 S353 -- 386 E351 D370 D360 E364 N354 -- 387 S352 A371 T361 D365 P355 K312 388 E353 E372 E362 E366 D356 D313 389 V354 V373 V363 V367 V357 L314 390 L355 N374 E364 S368 Q358 S315 391 R356 R375 R365 R369 A359 P316 392 G357 A376 A366 A370 A360 A317 393 K358 K377 K367 K371 K361 I318 394 N359 A378 S368 N372 N362 N319 395 L360 Q379 L369 Q373 K363 Y320 396 L361 L380 L370 L374 L364 T321 397 R362 K381 K371 K375 K365 K322 398 N363 A382 L372 S376 A366 L323 399 A364 A383 Q373 S377 G367 K324 bfc1 MPPB ysc1 MPPA bfc2 ysc2 400 L365 L384 L374 L378 Y368 N325 401 V366 L385 G375 L379 L369 A326 402 S367 L386 Q376 M380 M370 V327 403 H368 S387 L377 N381 S371 Q328 404 L369 L388 Y378 L382 V372 N329 405 D370 D389 E379 E383 E373 -- 406 G371 G390 S380 S384 S374 -- 407 T372 S391 G381 K385 S375 -- 408 T373 T392 N382 L386 E376 -- 409 P374 A393 P383 V387 G377 -- 410 V375 I394 V384 E388 F378 -- 411 C376 V395 N385 L389 L379 -- 412 E377 E396 D386 E390 D380 -- 413 D378 D397 A387 D391 E381 -- 414 -- -- N388 -- -- -- 415 -- -- L389 -- -- -- 416 I379 I398 L390 M392 V382 -- 417 G380 G399 G391 G393 G383 -- 418 R381 R400 A392 R394 S384 -- 419 S382 Q401 E393 Q395 Q385 -- 420 L383 V402 V394 V396 A386 -- 421 L384 V403 L395 L397 L387 E330 422 T385 T404 I396 M398 A388 S331 423 Y386 T405 K397 H399 A389 V332 424 G387 G406 G398 G400 G390 S333 425 R388 K407 S399 R401 S391 S334 426 R389 R408 K400 K402 Y392 P335 427 I390 L409 L401 I403 T393 I336 428 P391 S410 S402 P404 P394 E337 429 L392 P411 L403 V405 P395 L338 430 A393 E412 G404 N406 S396 N339 431 E394 E413 E405 E407 T397 F340 432 W395 V414 A406 M408 V398 D341 433 E396 F415 F407 I409 L399 A342 434 S397 E416 K408 S410 Q400 V343 435 R398 Q417 K409 K411 Q401 K344 436 I399 V418 I410 I412 I402 D345 437 A400 D419 D411 E413 D403 F346 438 E401 K420 A412 D414 A404 K347 439 V402 I421 I413 L415 V405 L348 440 D403 T422 T414 K416 A406 -- 441 A404 K423 V415 P417 D407 -- 442 R405 D424 K416 D418 A408 -- 443 V406 D425 D417 D419 D409 -- 444 V407 I426 V418 I420 V410 -- 445 R408 I427 K419 S421 I411 -- 446 E409 M428 A420 R422 N412 -- 447 V410 W429 W421 V423 A413 -- 448 C411 A430 A422 A424 A414 -- 449 S412 N431 G423 E425 K415 -- bfc1 MPPB ysc1 MPPA bfc2 ysc2 450 K413 Y432 K424 M426 K416 -- 451 Y414 R433 R425 I427 -- -- 452 F415 L434 L426 F428 F417 -- 453 Y416 Q435 W427 T429 V418 -- 454 D417 N436 D428 G430 S419 -- 455 Q418 K437 Q429 N431 G420 G349 456 C419 P438 D430 V432 R421 K350 457 P420 V439 I431 N433 K422 F351 458 A421 S440 A432 N434 S423 N352 459 V422 M441 I433 A435 M424 Y353 460 A423 V442 A434 G436 A425 V354 461 G424 A443 G435 N437 A426 A355 462 F425 L444 T436 G438 S427 V356 463 G426 G445 G437 K439 G428 G357 464 P427 N446 Q438 G440 N429 D358 465 I428 T447 I439 R441 L430 V359 466 E429 S448 E440 A442 G431 S360 467 Q430 T449 G441 T443 H432 N361 468 L431 V450 L442 V444 T433 L362 469 P432 P451 L443 V445 P434 P363 470 D433 N452 D444 M446 F435 Y364 471 Y434 V453 Y445 Q447 I436 L365 472 N435 S454 M446 G448 D437 D366 473 R436 Y455 R447 D449 E438 E367 474 I437 I456 I448 R450 L439 L368 475 R438 E457 R449 G451 -- -- 476 S439 E458 S450 S452 -- -- 477 G440 K459 D451 F453 -- -- 478 M441 L460 M452 G454 -- -- 479 F442 N461 S453 D455 -- -- 480 W443 Q462 M454 V456 -- -- 481 L444 -- M455 E457 -- -- 482 R445 -- R456 N458 -- -- 483 F446 -- W457 V459 -- -- 484 -- -- -- L460 -- -- 485 -- -- -- K461 -- -- 486 -- -- -- A462 -- -- 487 -- -- -- Y463 -- -- 488 -- -- -- G464 -- -- 489 -- -- -- L465 -- -- 490 -- -- -- G466 -- -- 491 -- -- -- N467 -- -- 492 -- -- -- S468 -- -- 493 -- -- -- S469 -- -- 494 -- -- -- S470 -- -- 495 -- -- -- S471 -- -- 496 -- -- -- K472 -- -- 497 -- -- -- N473 -- -- 498 -- -- -- D474 -- -- 499 -- -- -- S475 -- -- 500 -- -- -- P476 -- -- 501 -- -- -- K477 -- -- 502 -- -- -- K478 -- -- 503 -- -- -- K479 -- -- 504 -- -- -- G480 -- -- 505 -- -- -- W481 -- -- 506 -- -- -- F482 -- -- 507 447 463 458 483 440 369 bfc1 MPPB ysc1 MPPA bfc2 ysc2 >beefcore1 -------------TATYAQALQSVPETQVSQLDNGLRVASEQS-SQPTCTVGVWIDAGSRYESEKNNGAGYFVEHLAFKGTKNRPGNALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLAD---IVQNCSLEDSQIEKERDVILQELQEND-TSMRDVVFNYLHATAFQGTPLAQSVEGPSENVRKLSRADLTEYLSRHYKAPRMVLAAAGGLEHRQLLDLAQKHFSGLS----GTYDEDAVPTLSPCRFTGSQICHRED-----GLPLAHVAIAVEGPGWAHPDNVALQVANAIIGHYDCTYG--GGAHLSSPLASIAATNKL-CQSFQTFNICYADTGLLGAHFVCDH---MSIDDMMF-VLQGQWMRLCT- SATESEVLRGKNLLRNALVSHLDGTTPVCED--IGRSLLTYGRRIPLAEWESRIAEVDARVVREVCSKYFYDQCPAVAGFGPIEQLPDYNRIRSGMFWLRF----------------------->MPP_beta_Sc -mfsrtaskfrntrrllstisSQIPGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAVDILSD---ILTKSVLDNSAIERERDVIIRESEEVD-KMYDEVVFDHLHEITYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHEKLVQYAQKYFGHVP--KSESPVPLGSPRGPLPVFCRGERFIKEN-----TLPTTHIAIALEGVSWSAPDYFVALATQAIVGNWDRAIG--TGTNSPSPLAVAASQNGSLANSYMSFSTSYADSGLWGMYIVTDS--NEHNVRLIVNEILKEWKRIKSG KISDAEVNRAKAQLKAALLLSLDGSTAIVED--IGRQVVTTGKRLSPEEVFEQVDKITKDDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ-------------------------->yeastcore1 MLRTVTSKTVSNQFKRSLATAVATPKAEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENS-------AVAAKEGLALSSNISRDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLKQVQDFEENDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNAVVVGTGNIKHEDLVNSIESKNLSLQ-------TGTKPVLKKKAAFLGSEVRLRDD-----TLPKAWISLAVEGEPVNSPNYFVAKLAAQIFGSYNAFE---PASRLQGIKLLDNIQEYQLCDNFNHFSLSYKDSGLWGFSTATRN--VTMIDDLIH-FTLKQWNRLTI- SVTDTEVERAKSLLKLQLGQLYESGNPVNDANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRLWDQDIAIAGTGQIEGLLDYMRIRSDMSMMRW----------------------->MPP_alph_Sc --------MLRNGVQRLYSNIARTDNFKLSSLANGLKVATSNT-PGHFSALGLYIDAGSRFEGRNLKGCTHILDRLAFKSTEHVEGRAMAETLELLGGNYQCTSSRENLMYQASVFNQDVGKMLQLMSET---VRFPKITEQELQEQKLSAEYEIDEVW-MKPELVLPELLHTAAYSGETLGSPLICPRELIPSISKYYLLDYRNKFYTPENTVAAFVG-VPHEKALELTEKYLGDWQ-------STHPPITKKVPQYTGGESCIPPAPVFGNLPELFHIQIGFEGLPIDHPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTHVLNQYYFVENCVAFNHSYSDSGIFGISLSCIPQ AAP QAVE VIAQQMYNTFANKDL-RLTEDEVSRAKNQLKSSLLMNLESKLVELED--MGRQVLMHGRKIPVNEMISKIEDLKPDDISRVAEMIFTGNVNNAGNGKGRATVVMQGDRGSFGDVENVLKAYGLGNSSSSKNDSPKKKGWF>beefcore2 ---SLKVAPKVKATEAPAGVPPHPQDLEFTRLPNGLVIASLEN-YAPASRIGLFIKAGSRYENSNNLGTSHLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTRENMAYTVECLRDDVDILMEFLLN---VTTAPEFRRWEVAALQPQLRIDKAVAL-QNPQAHVIENLHAAAYRN-ALANSLYCPDYRIGKVTPVELHDYVQNHFTSARMALIGLG-VSHPVLKQVAEQFLNIRG---------GLGLSGAKAKYHGGEIREQN------GDSLVHAALVAESAAIGSAEANAFSVLQHVLGAGPHVK---RGSNATSSLYQAVAKGVHQPFDVSAFNASYSDSGLFGFYTISQ---AASAGDVIK-AAYNQVKTIAQG NLSNPDVQAAKNKLKAGYLMSVESSEGFLDE--VGSQALAAGSYTPPSTVLQQIDAVADADVINAAKK-FVSGRKSMAASGNLGHTPFIDEL-------------------------------->yeastcore2 --------------------MLSAARLQFAQGSVRRLTVSARDAPTKISTLAVKVHGGSRYATKD--GVAHLLNRFNFQNTNTRSALKLVRESELLGGTFKSTLDREYITLKATFLKDDLPYYVNALAD---VLYKTAFKPHELTESVLPAARYDYAVAEQCPVKSAEDQLYAITFRK-GLGNPLLYDG--VERVSLQDIKDFADKVYTKENLEVSGENVVEADLKRFVDESLLSTLP------AGKSLVSKSEPKFFLGEENRVRF-------IGDSVAAIGIPVNK---ASLAQYEVLANYLT-----------SALSELSGLI----------SSAKLDKFTDGGLFTLFVRDQ---DSAVVSSNIKKIVADLKKG-------KDLSPAINYTKLKNAVQN----------------ESVSSPIELNFDAVKDFKL---------------GKFNYVAVGDVSNLPYLDEL--------------------------------
10 20 30 40 50 60 | | | | | |beefcore2 ----------------SLKVAPKVKATEAPAGVPPHP--QDLEFTRLPNGLVIASLEN-Ychickcore2 MRRFSLPARSLAKRLYSLKVAPKVAVSAAAERVKLCPGAEDLEITKLPNGLIIASLEN-Fbeefcore1 ----------------------------TATYAQALQSVPETQVSQLDNGLRVASEQS-Schickcore1 -------------GRVLRGLLPLTRNRGAATYAQTLQNIPETNVTTLDNGLRVASEES-SMPP_beta_Sc ----------------MFSRTASKFRNTRRLLSTISSQIPGTRTSKLPNGLTIATEYIPNyeastcore1 ---------------MLRTVTSKTVSNQFKRSLATAVATPKAEVTQLSNGIVVATEHNPSMPP_alph_Sc -----------------------MLRNGVQRLYSNIARTDNFKLSSLANGLKVATSNT-Pyeastcore2 -----------------------------------MLSAARLQFAQGSVRRLTVSARDAP . : .: Prim.cons. MRRFSLPARSLAK33----2-223-2N2AA222QTL2S3P22EVTQLPNGL2VASEEN-S 70 80 90 100 110 120 | | | | | |beefcore2 APASRIGLFIKAGSRYENSNNLGTSHLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTchickcore2 SPASRIGVFIKAGSRYETTANLGTAHLLRLASPLTTKGASSFRITRGIEAVGGSLSVYSTbeefcore1 QPTCTVGVWIDAGSRYESEKNNGAGYFVEHLAFKGTKNRPGNALEKEVESMGAHLNAYSTchickcore1 QPTCTVGVWIGAGSRYENEKNNGAGYFVEHLAFKGTKKRPCAAFEKEVESMGAHFNGYTSMPP_beta_Sc TSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRPQQGIELEIENIGSHLNAYTSyeastcore1 AHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENS-------AVAAKEGLALSSNISMPP_alph_Sc GHFSALGLYIDAGSRFEGRNLKGCTHILDRLAFKSTEHVEGRAMAETLELLGGNYQCTSSyeastcore2 TKISTLAVKVHGGSRYATKD--GVAHLLNRFNFQNTNTRSALKLVRESELLGGTFKSTLD . :.: . .*: * : : * . Prim.cons. 3PTSTVGVFIDAGSRYENEKNNGTAHLLEHLAFKGTK2R22FAIEREIE33GGHL23YSS 130 140 150 160 170 180 | | | | | |beefcore2 RENMAYTVECLRDDVDILMEFLLN---VTTAPEFRRWEVAALQPQLRIDKAVAL-QNPQAchickcore2 REKMTYCVECLRDHVDTVMEYLLN---VTTAPEFRPWEVTDLQPQLKVDKAVAF-QSPQVbeefcore1 REHTAYYIKALSKDLPKAVELLAD---IVQNCSLEDSQIEKERDVILQELQEND-TSMRDchickcore1 REQTAFYIKALSKDMPKVVELLAD---VVQNCALEESQIEKERGVILQELKEMD-NDMTNMPP_beta_Sc RENTVYYAKSLQEDIPKAVDILSD---ILTKSVLDNSAIERERDVIIRESEEVD-KMYDEyeastcore1 RDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLKQVQDFEENDHPNMPP_alph_Sc RENLMYQASVFNQDVGKMLQLMSET---VRFPKITEQELQEQKLSAEYEIDEVW-MKPELyeastcore2 REYITLKATFLKDDLPYYVNALAD---VLYKTAFKPHELTESVLPAARYDYAVAEQCPVK *: : :: : : : . Prim.cons. RENTAYY2K3L2DDVPK2VELLAD---VVTAP2L22SEIE3ER3VIL2E22EVD-Q2PQN 190 200 210 220 230 240 | | | | | |beefcore2 HVIENLHAAAYRN-ALANSLYCPDYRIGKVTPVELHDYVQNHFTSARMALIGLG-VSHPVchickcore2 GVLENLHAAAYKT-ALANPLYCPDYRIGKITSEQLHHFVQNNFTSARMALVGIG-VKHSDbeefcore1 VVFNYLHATAFQGTPLAQSVEGPSENVRKLSRADLTEYLSRHYKAPRMVLAAAGGLEHRQchickcore1 VTFDYLHATAFQGTALARTVEGTTENIKHLTRADLASYIDTHFKAPRMVLAAAGGISHKEMPP_beta_Sc VVFDHLHEITYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHEKyeastcore1 RVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNAVVVGTGNIKHEDMPP_alph_Sc VLPELLHTAAYSGETLGSPLICPRELIPSISKYYLLDYRNKFYTPENTVAAFVG-VPHEKyeastcore2 SAEDQLYAITFRK-GLGNPLLYDG--VERVSLQDIKDFADKVYTKENLEVSGENVVEADL : *: :: *. . : : : : : . . : Prim.cons. VVFE3LHA2A2QGT2LANPL3GPDENI3K2TRADL2DY332H2T23RMVLAGAG2V3HE2 250 260 270 280 290 300 | | | | | |beefcore2 LKQVAEQFLNIRG---------GLGLSGAKAKYHGGEIREQN------GDSLVHAALVAEchickcore2 LKQVAEQFLNIRS---------GAGTSSAKATYWGGEIREQN------GHSLVHAAVVTEbeefcore1 LLDLAQKHFSGLS----GTYDEDAVPTLSPCRFTGSQICHRED-----GLPLAHVAIAVEchickcore1 LVDAARQHFSGVS-F---TYKEDAVPILPRCRFTGSEIRARDD-----ALPVAHVALAVEMPP_beta_Sc LVQYAQKYFGHVP--KSESPVPLGSPRGPLPVFCRGERFIKEN-----TLPTTHIAIALEyeastcore1 LVNSIESKNLSLQ-------TGTKPVLKKKAAFLGSEVRLRDD-----TLPKAWISLAVEMPP_alph_Sc ALELTEKYLGDWQ-------STHPPITKKVPQYTGGESCIPPAPVFGNLPELFHIQIGFEyeastcore2 KRFVDESLLSTLP------AGKSLVSKSEPKFFLGEENRVRF-------IGDSVAAIGIP .. : : : Prim.cons. LVQVAE23LS2LS-------7E2AVP243KARFTGGEIR2R3D-----GLPLAH2AIAVE 310 320 330 340 350 360 | | | | | |beefcore2 SAAIGSAEANAFSVLQHVLGAGPHVK---RGSNATSSLYQAVAKGVHQPFDVSAFNASYSchickcore2 GAAVGSAEANAFSVLQHVLGAGPLIK---RGSSVTSKLYQGVAKATTQPFDASAFNVNYSbeefcore1 GPGWAHPDNVALQVANAIIGHYDCTYG--GGAHLSSPLASIAATNKL-CQSFQTFNICYAchickcore1 GPGWADPDNVVLHVANAIIGRYDRTFG--GGKHLSSRLAALAVEHKL-CHSFQTFNTSYSMPP_beta_Sc GVSWSAPDYFVALATQAIVGNWDRAIG--TGTNSPSPLAVAASQNGSLANSYMSFSTSYAyeastcore1 GEPVNSPNYFVAKLAAQIFGSYNAFE---PASRLQGIKLLDNIQEYQLCDNFNHFSLSYKMPP_alph_Sc GLPIDHPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTHVLNQYYFVENCVAFNHSYSyeastcore2 VNK---ASLAQYEVLANYLT-----------SALSELSGLI----------SSAKLDKFT .. . : Prim.cons. G23W2SPD33ALSVLQAILGA2DR2K2--3GS2LSS2L2222A2N2L3CFSFSAFNTSYS 370 380 390 400 410 420 | | | | | |beefcore2 DSGLFGFYTISQ---AASAGDVIK-AAYNQVKTIAQGNLSNPDVQAAKNKLKAGYLMSVEchickcore2 DSGLFGFYTISQ---AAHAGEVIR-AAMNQLKAAAQGGVTEEDVTKAKNQLKATYLMSVEbeefcore1 DTGLLGAHFVCDH---MSIDDMMF-VLQGQWMRLCT-SATESEVLRGKNLLRNALVSHLDchickcore1 DTGLFGFHFVADP---LSIDDMM--CAQGEWMRLCT-STTESEVKRAKNHLRSAMVAQLDMPP_beta_Sc DSGLWGMYIVTDS--NEHNVRLIVNEILKEWKRIKSGKISDAEVNRAKAQLKAALLLSLDyeastcore1 DSGLWGFSTATRN--VTMIDDLIH-FTLKQWNRLTI-SVTDTEVERAKSLLKLQLGQLYEMPP_alph_Sc DSGIFGISLSCIPQAAPQAVEVIAQQMYNTFANKDL-RLTEDEVSRAKNQLKSSLLMNLEyeastcore2 DGGLFTLFVRDQ---DSAVVSSNIKKIVADLKKG-------KDLSPAINYTKLKNAVQN- * *: :: . : Prim.cons. DSGLFGFYTV322--AAS22DVI8-AA3NQWKRL22-S2TESEVSRAKNQLKAALLMSLE 430 440 450 460 470 480 | | | | | |beefcore2 SSEGFLDE--VGSQALAAGSYTPPSTVLQQIDAVADADVINAAKK---FVSGRKSMAASGchickcore2 TAQGLLNE--IGSEALLSGTHTAPSVVAQKIDSVTSADVVNAAKK---FVSGKKSMAASGbeefcore1 GTTPVCED--IGRSLLTYGRRIPLAEWESRIAEVDARVVREVCSKY--FYDQCPAVAGFGchickcore1 GTTPVCET--IGSHLLNYGRRISLEEWDSRISAVDARMVRDVCSKY--IYDKCPALAAVGMPP_beta_Sc GSTAIVED--IGRQVVTTGKRLSPEEVFEQVDKITKDDIIMWANYR--LQNKPVSMVALGyeastcore1 SGNPVNDANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKR--LWDQDIAIAGTGMPP_alph_Sc SKLVELED--MGRQVLMHGRKIPVNEMISKIEDLKPDDISRVAEM---IFTGNVNNAGNGyeastcore2 -----------------ESVSSPIELNFDAVKDFKL---------------GKFNYVAVG . . . : . .. *Prim.cons. 22TPVLED--IG2QVLTYGRRIP2EEVFSKIDAVTA3DV2NVA2K3--F2DG232MAA2G 490 500 510 520 | | | |beefcore2 NLGHTPFIDEL---------------------------------chickcore2 DLGSTPFLDEL---------------------------------beefcore1 PIEQLPDYNRIRSGMFWLRF------------------------chickcore1 PIEQLLDYNRIRSGMYWIRF------------------------MPP_beta_Sc NTSTVPNVSYIEEKLNQ---------------------------yeastcore1 QIEGLLDYMRIRSDMSMMRW------------------------MPP_alph_Sc KGRATVVMQGDRGSFGDVENVLKAYGLGNSSSSKNDSPKKKGWFyeastcore2 DVSNLPYLDEL---------------------------------Prim.cons. 3IEQLPDYD2IRS2M-2-2------------------------F