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ProteinSequence
@nalysis
Chlorobiumlimicola
MAENTPKPAAGTAPAKPKPAAPGAAKPAAPKAARPGAAKPAAKPAAPRAAAPSG-----VYKKPPVDRPDP
Sacch. Cere
sequence:
0 10
-
20
--30
40
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Rhdbactersphaer. MSGIPHDHYEPRTGIEKWLHSRLPIVALAYDTIM-IPTPRNLN--WMWIWGVVLAFCLVLQIV (a pro)
Paracoccus
MAGIPHDHYEPKTGFERWLHRRLPIVSLVYDTLM-IPTPKNLN--WWWIWGIVLAFCLVLQIA (a pro)
Rickettsiap
-MNKEIIHKKSNGIIEWIDYRLPIFSFLKHFSY-YQTPKNLN--YLWNLGSIAGIALVIQII (a pro)
HHHHHHHHHH
HHHHHHHHHHHH
HHHHHHHHHHHHHHHHHH
Bostaurus
---------------MTNIRKSHPLMKIVNNAFIDLPAPSNIS--SWWNFGSLLGICLILQIL (mito)
chicken
--------------MAPNIRKSHPLLKMINNSLIDLPAPSNIS--AWWNFGSLLAVCLMTQIL (mito)
cichlasoma_boliv ----------------ASLRKTHPLLKIANDALVDLPAPSNIS--IWWNFGSLLGLCLAAQIL
Saccharocere
----------------MAFRKSNVYLSLVNSYIIDSPQPSSIN--YWWNMGSLLGLCLVIQIV (mito)
Soltuber
----------MTIRNQRLSLLKQPISSTLNQHLIDYPTPSNLS--YWWGFGSLAGICLVIQIV (mito)
Polytomel
----------------MRLHQKNNMLQLYYQHIEAYPTPCNLK--YSWNMGSLSGLLLASQIV (mito)
Chromatiumvinosum -------MSAEKTENLSWIDKRFPLSETWRNHLSEYYAPKNLN--FWSFFGSLAILTLVIQIV (g pro)
Aquifexa
--------MGLIEKIVDWIDERAHVREIYRTQMVEYKVAKNLT--FPYVFGILALVTFAIQII
(Aqui)
Chlorobiumlimicola
NPFKDSKRDAVAGWFQERFYVLNPIIDYLKHKEVPKHALS-FWYYFGGLGLFFFVIQIL
B.stearothp
------MLNKLYDWVDERLDITPLWRDIADHEVPEHVNPAHHFSAFVYCFGGLTFFVTVIQIL
(firmic)
Synechpcc
-----MFSKEVTESKVFQWFNDRLEVQAISDDIASKYVPPHVN--IFYCLGGLTLTCFLIQFA (cyanob)
Spinacia
------------MSKVYDWFEERLEIQAIADDITSKYVPPHVN--IFYCLGGITLTCFLVQVA (cplst
Chlamyrb6
------------MSKVYDWFEERLEIQAIADDITSKYVPPHVN--IFYCIGGITFTCFLVQVA
*
:. * : ::
*.
50
60
70
80
- 90
100
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*- |
*
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Rhdbactersphaer. TGIVLAMHYTPHVDLAFASVEHIMRNVNGGFMLRYLH-ANGASLFFIAVYLHIFRGLYYGS
Paracoccus
TGIVLVMHYTPHVDLAFASVEHIMRDVNGGYMLRYLH-ANGASLFFLAVYIHIFRGLYYGS
Rickettsiap
TGVILAMHYTPHVDHAFESVERIMRNVNYGWLLRYTH-AVGASMFFAAIYLHIARGLYYGS
Bostaurus
TGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMH-ANGASMFFICLYMHVGRGLYYGS
chicken
TGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLH-ANGASFFFICIFLHIGRGLYYGS
cichlasoma_boliv TGLFLAMHYTSDIATAFSSVAHICRDVNYGWLIRNMH-ANGASFFFICIYLHIGRGLYYGS
Saccharocere TGIFMAMHYSSNIELAFSSVEHIMRDVHNGYILRYLH-ANGASFFFMVMFMHMAKGLYYGS
Soltuber TGVFLAMHYTPHVDLAFNSVEHIMRDVEGGWLLRYMH-ANGASMFFIVVYLHIFRGLYYAS
Polytomella
TGILLAMHYCPDTSLAFYSVIHLTVDVPYGFVIRYFH-MNGASLFFVAVFLHLFRNLYYNS
Chromatiumvinosum TGVWLAMSYKPDAGLAFASVEYIMRDVDWGWLIRYMH-STGASMFFIVIYLHMFRGLLRGS
Aquifexa
SGMVLILYYNLQSQTLL-TVHLLDNGRNSLRMALQAHTRTGANFFMAIVYLHMFTGIYYNA
Chlorobiumlimicol TGLLLLQYYKPTETDAFASFLFIQGEVPFGWLLRQIH-AWSANLMIMMLFIHMFSTFFMKS
B.stearothp
SGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMH-HWGASLVIVMMFLHTVRVFFQGA
Synechpcc
TGFAMTFYYKPTVTEAFASVQYIMNEVNFGWLIRSIH-RWSASMMVLMMILHVFRVYLTGG
Spinacia
TGFAMTFYYRPTVTDAFASVQYIMTEVNFGWLIRSVH-RWSASMMVLMMILHVFRVYLTGG
Chlamyrb6
TGFAMTFYYRPTVAEAFASVQYIMTDVNFGWLIRSIH-RWSASMMVLMMVLHVFRVYLTGG
**.
:.: * . ** ** : :*. *:::*
:*
.**::.: : :*: : ..
Chlorobiumlimicola
------------------------------------
110
120
130
140
150
---------- 160
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Rhdbactersphaer. YKAPREVTWIVGMLIYLAMMATAFMGYVLPWGQMSFWGATVITGLFG----------AIPGIGHSIQTWL
Paracoccus
YKAPREVTWIVGMLIYLMMMGTAFMGYVLPWGQMSFWGATVITGLFG----------AIPGVGEAIQTWL
Rickettsiap
YKTPRELLWHIGIIIFLIMMATAFMGYVLPWGQMSYWGATVITNLFS----------AIPLVGEPIVIWL
Bostaurus
YT--FLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLS----------AIPYIGTNLVEWI
chicken
YL--YKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFS----------AIPYIGHTLVEWA
cichlasoma_boliv YL--YKETWNVGVVLLLLVMMTAFVGYVLPWGQMSFWGATVITNLLS----------AVPYIGNSLVQWL
Saccharocere YRSPRVTLWNVGVIIFILTIATAFLGYCCVYGQMSHWGATVITNLFS----------AIPFVGNDIVSWL
Soltuber
YSSPREFVRCLGVVIFLLMIVTAFIGYVLPWGQMSFWGATVITSLAS----------AIPVVGDTIVTWL
Polytomella
GSQPRELLYISGVVILLLMVITAFIGYVLPWGQMSFWGATVITSLVS----------AVPIVGTDLVYYL
Chromatiumvinosum YRKPRELLWMIGVVIYLVMMATAFFGYLLPWGQMSYWGAQVIVNLFA----------AVPVVGEDLSVWV
Aquifexa
YKRPRELVWIVGWLIYFVLILTALSGYLLPWGQLSYWGFIVTTEIPGSLADAPILKPIFKAIAETIVLWM
Chlorobiumlimicol YRKPRELMWVSGFVLLLLSLGFGFTGYLLPWNELAFFATQVGTEVPK----------VAPG-GAFLVEIL
B.stearothp
YKKPREMNWIVGVLIFMVMMGLGFTGYLLPWDMKALFATKVGLQIVE----------AVPLIGPAIKTLL
Synechpcc
FKKPRELTWVVGVMLAVTTVTFGVTGYSLPWDQVGYWAVKIVSGVPA----------AIPVVGDQLVTLM
Spinacia
FKKPRELTWVTGVVLGVLTASFGVTGYSLPWDQIGYWAVKIVTGVPD----------AIPVIGSPLVELL
Chlamyrb6
FKRPRELTWVTGVIMAVCTVSFGVTGYSLPWDQVGYWAVKIVTGVPD----------AIPGVGGFIVELL
:
. *:::
: ..
** :.*:..*.. :: .: *:* :* : DCCD-Binding
170
- 180 -
190
200
210
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- |
-
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Rhdbactersphaer. LGGPAVDNA-TLNRFFSLH-YLLPFVIAALVAIHIWAFHSTGNNNPTGVEVRRTSK-----
Paracoccus
LGGPAVDNP-TLNRFFSLH-YLLPFVIAALVVVHIWAFHTTGNNNPTGVEVRRGSK-----
Rickettsiap
WGGFSVDNP-TLNRFFALH-YLFPFIIVVLVILHLVALHQHGSNNPKGIDVK---------
Bostaurus
WGGFSVDKA-TLTRFFAFH-FILPFIIMAIAMVHLLFLHETGSNNPTGIS-----------
chicken
WGGFSVDNP-TLTRFFALH-FLLPFAIAGITIIHLTFLHESGSNNPLGIS-----------
cichlasoma_boliv WGGFSVDNA-TLTRFFAFH-FLLPFIIAAMTMIHLIFLHETGSTNPAGLN-------------
Saccharocere WGGFSVSNP-TIQRFFALH-YLVPFIIAAMVIMHLMALHIHGSSNPLGIT-----------
Soltuber
WGGFSVDNA-TLNRFFSLH-YLLPFILVGASLLHLAALHQYGSNNPLGVH-----------
Polytomella
WGGFSVSNP-TLNRFFSFH-YLLPFVLAGLSIAHLAALHSYGSTNPLSIN-----------
Chromatiumvinosum RGDFVISDA-TLNRFFAFH-FLLPFLLAGLVFLHIVALHHVGSNNPDGIEIKEGPKGNRWS
Aquifexa
KGGYVVTDV-TLGRVFGSHVLIYPLILLALVGIHLYLVRAAGISNPEGIEYDKKK------
Chlorobiumlimicol RGGPEVGGE-TLTRMFSLHVVLLPGLVMLVLAAHLTLVQILGTSAPIGYKEAG-----LIK
B.stearothp
AGDPEIVGAQTLARFFAIHVFFLPAALLGLMAAHFLMIRRQGISGPLMHRGKGMKFVGDSR
Synechpcc
RGSESVGQA-TLTRFYSLHTFVLPWAIAVLLLLHFLMIRKQGISGPLMSIMKKPDLSDP-K
Spinacia
RGSASVGQS-TLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPLMGVTKKPDLNDP-V
Chlamyrb6
RGGVGVGQA-TLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
*.
:...*: **:::* .::*
:*:
:: * ..*
220
230
240
------250
260
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------
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Rhdbactersphaer. AEAQKDT-VPFWPYFIIKDVFALAVVLLVFFAIVGFMP------NYLGHPDNYIEANPLSTPA
Paracoccus
EEAKKDT-LPFWPYFVIKDLFALAVVLVVFFAIVGFMP------NYLGHPDNYIEANPLVTPA
Rickettsiap
--STKDT-IPFHPYYTVKDFVGFGVYFIIFAYFIFYAP------NYLGHPDNYIPANPLVTPA
Bostaurus
--SDVDK-IPFHPYYTIKDILGALLLILALMLLVLFAP------DLLGDPDNYTPANPLNTPP
chicken
--SDSDK-IPFHPYYSFKDILGLTLMLTPFLTLALFSP------NLLGDPENFTPANPLVTPP
cichlasoma_boliv --SDAEK-ISFHPYFSYKDLLGFAVLLVALIALALFSP------NLLGDPDNFIPANPLVTPP
Saccharocere --GNLDR-IPMHSYFIFKDLVTVFLFMLILALFVFYSP------NTLGQPDNYIPGNPLVTPA
Soltuber
--SEMDK-IASYPYFYVKDLVGWVAFAIFFSIWIFYAP------NVLGHPDNYIPANPMSTPP
Polytomella
---SVAK-VPFGSYYIIKDLLGVLIIGAAMIVLAFFFP------EALNHSDNYIPANPYSTPA
Chromatiumvinosum DKAPADG-IPFHPYYTVKDLMGVVVFLAIFGYVMFFNP---TMGGLFLEAPNFQPANPMQTPA
Aquifexa
---NPDKFVPFHPYMTLKEGAYVMWYLAVFFFFVFFHI------SHFLPPENFEPANPLKTPA
Chlorobiumlimicola
GYDKFFPTFLAKDGIGWLIGFALLIYLAVMFP------WEIGVKANPLSPAPL
B.stearothp
IPAVRKPNIPKDYSEYPGKTEVFWPNFLLKEWLVGSVFLVG-FLCLTVAHPSPLERIADPTDTTY
B.stearothp?
GDSRIPAVRKPNIPKDYSEYPGKTEVFWPNFLLKEWLVGSVFLVGFLCLTVAHPSPLERIADPTDTTY
Synechpcc
LRAKLAQ-NMGHNYYG--EPAWPNDILFTFPICIAGTIGLITGLAILDPAMIGEPGNPFATPL
Spinacia
LRAKLAK-GMGHNYYG--EPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPL
.
*:
.
.
.:*: **
270
280
290
300
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Rhdbactersphaer. HIVPEWYFLPFYAILRAFTADVWVVQIANFISFGIIDAKFFGVLAMFGAILVMAL-VPWLD
Paracoccus
HIVPEWYFLPFYAILRAFTADVWVVMLVNWLSFGIIDAKFFGVIAMFGAILVMAL-VPWLD
Rickettsiap
HIVPEWYFLPFYAILRAV------------------PSKLGGVFLMFGSIVVLFL-LPWLD
Bostaurus
HIKPEWYFLFAYAILRSI------------------PNKLGGVLALAFSILILAL-IPLLH
chicken
HIKPEWYFLFAYAILRSI------------------PNKLGGVLALAASVLILFL-IPFLH
cichlasoma_boliv HIKPEWYFLFAYAILRSI------------------PNKLGGVLALLFSILILML-VPILH
Saccharocere SIDPEWYLLPFYAILRSI------------------PDKLLGVITMFAAILVLLV-LPFTD
Soltuber
HIVPEWYFLPIYAILRSI------------------PDKVGGVAAIALVFICLLA-LPFFK
Polytomella
HIVPEWYFLPVYAILRSI------------------PDKGIGILAVLLFFIGLGL-QPFLS
Chromatiumvinosum HIAPVWYFTPFYAMLRAV--------------PPMYGSQFPGVVVMFAAILILFV-LPWLD
Aquifexa
HIAPEWYLLGYYEVFRSI------------------PSKFWGFVAFNALLLLLLL-LPFLD
Chlorobiumlimicol GIKPEWYFWAQFQLLK--------------------DFKFEGGELLAIILFTIGG-VVWLL
B.st.
IPLPDWYFLFLYQLLKYSY--------------ASGPYTVIGAIVMPGLAFGALLLAPFLD
Synechpcc
EILPEWYLYPVFQILRVL------------------PNKLLGIACQGAIPLGLMM-VPFIE
Spinacia
EILPEWYFFPVFQILRTV------------------PNKLLGVLLMASVPAGLLT-VPFLE
*
* **: .
:**
:.
*: : :* .
310
320
330
340
350
360
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Rhdbactersphaer. TSPVRSGRY-RPMFKIYFWLLAADFVILTWVGAQQTTFPYDWISLIASAYWFAYFLVILP
Paracoccus
TSRVRSGQY-RPLFKWWFWLLAVDFVVLMWVGAMPAEGIYPYIALAGSAYWFAYFLIILP
Rickettsiap
TSKIRSGNY-RPIYRIAFWIFMADCLFLGYLGSKPVSEPYITISRFAVCYYFCHFLLVLP
Bostaurus
TSKQRSMMF-RPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMP
chicken
KSKQRTMTF-RPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFP
cichlasoma_boliv TSKLRALTF-RPLTQCLFWLLVADVMILTWIGGMPVEHPFIIIGQIASILYFTIFLILLP
Saccharocere RSVVRGNTF-KVLSKFFFFIFVFNFVLLGQIGACHVEVPYVLMGQIATFIYFAYFLIIVP
Soltuber
SMYVRSSSF-RPIYQGMFWLLLADCLLLGWIGCQPVEAPFVTIGQISSLVFFLFFAI-TP
Polytomella
QGKA------EPHFYASFI---GGLFVLGWLGSKEITDVTSAAPSFFTLFTFAYLFVVSP
Chromatiumvinosum RSPVKSMRYKGPIFKWATGIFVVSFVALAWLGIQPASDFYTLLSQIFTVLYFAYFLL-MP
Aquifexa
FSPLKSA-RRRPLFFVMFVIFMISSMALTILGTMPPTPQNAKLGLIFAALVFAFFIS-LP
Chlorobiumlimicol VPFIDRQASEEKKSPIFTIFGILVLAFLLINTYRVYAEYSMLK----------------
B.st.
RGPE-RRPWKRPVATGMMLLTLAAIVYLTWESVVTHDWEKAAEQGKIRAEVEIDTN
Synechpcc
SVNKFQNPFRRPVAMAVF--LFGTAVTL-WLGAGA-CFPIDESLTLGLF------------
Spinacia
NVNKFQNPFRRPVATTVF--LVGTVVAL-WLGIGA-TLPIDKSLTLGLF------------
::
:
:
* .
370
380
|
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Rhdbactersphaer. ILGAIEKPVAPPATIEEDFNAHYSPATGGTKTVVAE
Paracoccus
LLGIIEKPDAMPQTIEEDFNAHYGPETHPAE-----
Rickettsiap
LIGKYEKPLPLPKVL---------------------
Bostaurus
TAGTIENKLLKW------------------------
chicken
TIGTLENKMLNY------------------------
cichlasoma_boliv TAGLTENKI---------------------------
Saccharocere VISTIENVLFYIGRVNK-------------------
Soltuber
ILGRVGRGIPNSYTDETDHT----------------
Polytomella
LYSLLYNRVKG-------------------------
Chromatiumvinosum IYSSLDKTKPFLRG----------------------
Aquifexa
IISFIEYGWYKAKGGQQE------------------
B.st. 181
aegykiaqantCTSCHgenlsggagpslvgtgltaeeiakiakegqgsmpggifkgtdee
Synechpcc
------------------------------------
Spinacia
------------------------------------
Bacillus
st.:N-term is suIV, C-term is cyt c1
1 MHRGKGMKFV GDSRIPAVRK PNIPKDYSEY PGKTEVFWPN
FLLKEWLVGS
VFLVGFLCLT
61 VAHPSPLERI
ADPTDTTYIP LPDWYFLFLY QLLKYSYASG
PYTVIGAIVM PGLAFGALLL
121 APFLDRGPER
RPWKRPVATG MMLLTLAAIV YLTWESVVTH
DWEKAAEQGK IRAEVeidtn
181 aegykiaqan tCTSCHgenl
sggagpslvg
tgltaeeiak
iakegqgsmp ggifkgtdee
241 lqkmansspa
Note suIV ends w
helix G
, so C-term on
periplasmic side where cyt c1 N-term
is.
BC1-LIKE VS B6F
LIKE:
Split cyt b
15 residues
between H ligands in helix D
H202 - R
C at start of
helix A