Two alternative alignmets for 50-80 region- structure suports first,
less parsimonious alignment:
This adds three residues in turn at tip of 1st branch of Y-loop, removes
3 from second branch.
P74 is cis-proline. interface w sym-related c1 extends P74 - G78 (in
vertebrates)
0 10
20 30
40 50
60 70
80
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Gallus
GELELHPPAFPWSHGGPLSALDHSSVRRGFQVYKQVCSACHSMDYVAFRNLI--G-VTHTEAEAKALAEEVEVQDGPDENGEL
Bostaurus
SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLV--G-VCYTEDEAKALAEEVEVQDGPNEDGEM
Saccharocere
MTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVCAACHSLDRVAWRTLV--G-VSHTNEEVRNMAEEFEYDDEPDEQGNP
Rb.capsulatus
NSNVQDHAFSFEGIFGKFDQAQLRRGFQVYSEVCSTCHGMKFVPIRTLSDDGGPQLDPTFVREYAAGLD--TIIDKDS-G
* * * . .:.:*..*::..:*::.:*******.:***:**.*.:*.
* * . .: :.. : * . *
Prim.cons. MKKLLISAVS2L2L22GAALANSNV22222S22G22222D2222RRGFQVY22VCS2CH2M22V22R2L22222222222222E22222D2
0 10
20 30
40 50
60 70
80
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|
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Gallus
GELELHPPAFPWSHGGPLSALDHSSVRRGFQVYKQVCSACHSMDYVAFRNLIGVTHTEAEAKALAEEVEVQDGPDENGEL
Bostaurus
SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEDEAKALAEEVEVQDGPNEDGEM
Saccharocere
MTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVCAACHSLDRVAWRTLVGVSHTNEEVRNMAEEFEYDDEPDEQGNP
Rb.capsulatus
NSNVQDHAFSFEGIFGKFDQAQLRRGFQVYSEVCSTCHGMKFVPIRTLSDDGGPQLDPTFVREYAAGLDTIIDKDSG
* * * . .:.:*..*::..:*::.:*******.:***:**.*.:*.
* * . .: :.. : * . *
Prim.cons. MKKLLISAVS2L2L22GAALANSNV22222S22G22222D2222RRGFQVY22VCS2CH2M22V22R2L22222222222222E22222D2
90 100
110 120
130 140
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Gallus FMRPGKISDYFPKPYPNPEAARADNNGALPPDLSYIVYARH
XXEDYVFSLLXXYX-XPPRALWC
Bostaurus FMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRARH-----------------GGEDYVFSLLTGYC-EPPTGVSLR
Saccharocere KKRPGKLSDYIPGPYPNEQAARAANQGALPPDLSLIVKARH-----------------GGCDYIFSLLTGYPDEPPAGVALP
Rb.capsulatus EERDRKETDMFPTRVG----------DGMGPDLSVMAKARAGFSGPAGSGMNQLFKGIGGPEYIYRYVTGFPEENPACAPEG
:... * * :* **. :
.: **** :.:**
** :*:: :**: * .. : .
Prim.cons. 2222222222R22K22D2FP 2222222222222G222PDLS2222AR2GFSGPAGSGMNQLFKGIGG22Y22222TG22E22222222G
secondary
HHHH3HHHHH
150
160 170
180 190
200 210
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Bostaurus -EGLYFNPYFP------------------GQAIGMAPPIYNEVLEFDDGTPATMSQVAKDVCTFLRWAAEPEHDHRKRMGLKMLLMMGLLL
Saccharocere -PGSNYNPYFP------------------GGSIAMARVLFDDMVEYEDGTPATTSQMAKDVTTFLNWCAEPEHDERKRLGLKTVIILSSLY
Rb.capsulatus IDGYYYNEVFQVGGVPDTCKDAAGIKTTHGSWAQMPPALFDDLVTYEDGTPATVDQMGQDVASFLMWAAEPKLVARKQMGLVAVVMLGLLS
:* *:* * .:
*. :::::: ::****** .*:.:** :** *.***: **::** ::::.
*
Prim.cons. I2G2Y2N22F222222DTCKDAAGIKTTHGSWAQMAP3LFDD3VEYEDGTPAT3SQMAKDV3TFL3WAAEPEHD3RKRMGLK3V3MLGLL3
secondary betaturn
220 230
240
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Bostaurus PLVYAMKRHKWSVLKSRKLAYRPPK---
Saccharocere LLSIWVKKFKWAGIKTRKFVFNPPKPRK
Rb.capsulatus VMLYLTNKRLWAPYKRQKA---------
: :: *: * :*
Prim.cons. 3L3Y33KK3KWA33K3RK3222PPKPRK